Consequently, a meta-analysis of GWAS studies (n = 74,046) identified 14 risk genes in AD, encompassing the ZCWPW1, SORL1, SLC24A4, RIN3, PTK2B, NME8, MEF2C, INPP5D, HLA-DRB4, HLA-DRB1, FERMT2, DSG2, CELF1, and CASS4 genes (12). This evidence concerns the gene RIN3 and Alzheimer disease.