FOXP3 and cancer: In 2015, Shang et al. analyzed the prognostic value of FoxP3+ Tregs in different types of cancer, and they reported that high FoxP3+ Tregs infiltration had a significant positive effect on OS (OR = 0.71, 95% CI 0.62–0.82) and DFS (OR = 0.63, 95% CI 0.48–0.88) (Shang et al., 2015).