Nevertheless, to the best of our knowledge, high infiltration of FoxP3+ Tregs was a strong factor for unfavorable outcome in various solid tumors, such as breast cancer (Shou et al., 2016), non-small cell lung cancer (Zhao et al., 2016) and hepatocellular carcinoma (Zhao et al., 2014). Here, FOXP3 is linked to hepatocellular carcinoma.