Accumulating evidence demonstrated that, in the majority of solid tumors, a high density of tumor-infiltrating FoxP3+ Tregs predicted an impaired patient survival (Wolf et al., 2005; Hiraoka et al., 2006; Miller et al., 2006; Takenaka et al., 2013; O'callaghan et al., 2015). The gene discussed is FOXP3; the disease is neoplasm.