However, the researches performed by Erdman et al. in mouse models of CRC demonstrated that adoptive transfer of Tregs was able to prevent bacteria-driven inflammation and carcinogenesis, when Tregs were previously exposed to enteric bacteria and could secrete IL-10 (Erdman et al., 2003a; Poutahidis et al., 2007). This evidence concerns the gene IL10 and colorectal carcinoma.