Recently, immunotherapy in patients with CRC has renewed scientific interest, such as checkpoint inhibition of cytotoxic T-lymphocyte associated protein 4 (CTLA-4), programmed cell death 1 (PD-1) and CD137 (Mazzolini et al., 2007; Correale et al., 2016). The gene discussed is CTLA4; the disease is colorectal carcinoma.