Paradoxically, not only no significant correlation between increased frequency of FoxP3+ Tregs and prognosis involving CRC patients was found in recent researches (Suzuki et al., 2010; Salama et al., 2012; Xu et al., 2013), but also several studies even reported that high FoxP3+ Tregs infiltration might be linked with a favorable prognosis in CRC (Reimers et al., 2014; Vlad et al., 2015; Argon et al., 2016; Chen et al., 2016). The gene discussed is FOXP3; the disease is colorectal carcinoma.