CREB1 and dementia: When dementia model rats underwent 7 days of continuous oral HJG administration, there was a significant increase in phosphorylated CREB (Vehicle, 0.41 ± 0.08-fold, n = 12; HJG, 1000 mg/kg, 0.85 ± 0.12-fold, n = 8, p < 0.01 vs. Vehicle).