Numerous features of AD-like neurodegeneration can be experimentally produced together with increasing oxidative stress through impairing selectively insulin signaling, and support that AD represents a neuroendocrine disturbance related with brain-specific perturbations in insulin signaling mechanisms, namely type 3 diabetes (Lester-Coll et al., 2006; Song et al., 2017). The gene discussed is INS; the disease is Alzheimer disease.