Both of the TSC1 or TSC2 KO mice are embryonic lethal; however, mice harboring TSC1 or TSC2 heterozygous mutations display synaptic dysfunction and cognitive impairments (Kobayashi et al., 2001; von der Brelie et al., 2006; Ehninger et al., 2008). This evidence concerns the gene TSC2 and Cognitive impairment.