To test the possibility that inflammation could interfere with Aβ metabolism in RR-MS patients, we investigated possible correlations between Aβ1–42 concentrations and the levels of some proinflammatory and anti-inflammatory molecules in the CSF (IL-1β, IL1-ra, IL-8, IL-10, IL12, TNFα, IFNγ). This evidence concerns the gene IL10 and myeloid sarcoma.