The primary findings of the present study were that: (1) iPS-NSC transplants improved motor abilities in HD-treated mice; (2) iPS-NSCs survived for at least 10 weeks after transplantation in both WT and HD mice brains; (3) iPS-NSCs differentiated into mature neurons and region-specific neurons (medium spiny neurons); (4) increases in protein levels of BDNF and TrkB were found in iPS-NSCs-treated HD mice; and (5) differentiation patterns of the transplanted iPS-NSCs were dissimilar between HD and WT mice. The gene discussed is BDNF; the disease is Huntington disease.