SELE and endothelial dysfunction: Endothelial dysfunction is characterized by elevated levels of endothelial lesion biomarkers and endothelial cell adhesion molecules, such as ICAM-1, VCAM-1, E-selectin, P-selectin, thrombomodulin, class 1 tissue plasminogen activator, and class 1 tissue plasminogen activator inhibitor (PAI-1) [109].