Multivariate linear regression analysis showed only FTC, large tumor size, blood vessel invasion, LNM > 5 and initial DM were significantly associated with preoperative serum Tg concentration (β = 662.93 and P < 0.001 for FTC, β = 48.82 and P < 0.001 for tumor size, β = 378.59 and P < 0.001 for blood vessel invasion, β = −70.19 and P = 0.045 for LNM > 5, β = 2049.32 and P < 0.001 for initial DM) (Table 2). The gene discussed is TG; the disease is neoplasm.