TRPC5 and neoplasm: We screened eight different types of tumor and non-tumor cells derived from human tissues by evaluating the TRPC4 mRNA gene expression with quantitative PCR (supplementary Fig. 1a) and measuring the functional expression of Ca2+-permeable TRPC4 and/or TRPC5 with Ca2+-response to 30 nM EA (supplementary Fig. 1b).