In cases of high grade serous carcinoma (n = 425), the positivity of ER or PR was 86%, or 60% in cases with lymph node metastases, which was not different to the positivity of ER or PR in cases without lymph node metastases (89%, or 55%, p = 0.235, or p = 0.372, respectively). This evidence concerns the gene ESR1 and metastatic malignant neoplasm in the lymph nodes.