In cases of clear-cell carcinoma (n = 135, Table 3), the positivity of ER or PR in cases with lymph node metastases was 9% or 18%, which was not different to the positivity of ER or PR in cases without lymph node metastases (21% or 11%, p = 0.693 or 0.352, respectively). This evidence concerns the gene ESR1 and metastatic malignant neoplasm in the lymph nodes.