IFNA1 and neoplasm: However, in a study by Prestwich and colleagues13 immunocompetent mice inoculated with these melanoma tumours and treated with with RV-loaded T cells had significant reduction in splenic and lymph node metastases, as well as an up-regulated IFN production of splenocytes secondary to tumour cell exposure, suggestive of an active adaptive anti-tumour response even in the absence of direct tumour lysis.