CD8A and Epstein-Barr virus infection: In these systematic studies, multiple complementary methods demonstrated that selective CD8 cross-reactive TCR repertoires (Fig. 4) between an individual’s memory responses to IAV-M1 and the early antigen EBV-BM played a role in the modification of antigen-specific CD8 T-cell frequencies and functions and disease severity during the acute phase of EBV infection.