However, in order to actually stratify each patient into the mild- or severe-AIM group, we scored AIM severity by using these same three direct measurements of AIM pathology, including the percentage of atypical lymphocytes in peripheral blood, the level of lymphadenopathy as scored by the same research nurse, and the CD4/CD8 ratio in PBMCs (details are in Materials and Methods) (Table S1). The gene discussed is CD8A; the disease is Lymphadenopathy.