2013; Shi et al. 2016) and significantly lower in individuals with Type 2 diabetes, (Moreno‐Navarrete et al. 2013) data from a meta‐analysis (Qiu et al. 2016) and a large cohort study found, the opposite, that irisin was positively associated with insulin resistance and metabolic risk factors (Park et al. 2013). This evidence concerns the gene FNDC5 and type 2 diabetes mellitus.