Taking into account that anle138b was also shown to ameliorate disease phenotypes in a mouse model for Tau pathology, thus being to the best of our knowledge one of the first compounds that seems to causatively interfere with both of the two major hallmarks of AD, we suggest that anle138b to further be validated in clinical trials for its potential to treat AD and perhaps other aggregopathies. This evidence concerns the gene MAPT and Alzheimer disease.