LGALS4 and Huntington disease: HD has been modelled several times in Drosophila by overexpression of pathological expansions under neuronal drivers (Lewis and Smith, 2016), and these models have similar phenotypes to ours, having reduced lifespan when expressed under elav-Gal4 and retinal neuron degeneration under GMR-Gal4 (Fig. 4); and in addition, they also show features typical of HD, such as protein aggregates.