In contrast, in men on antihypertensive treatment, hyperuricemia (> 410 mmol/L) was significantly associated with increased risk of HF even after adjustment for a wide range of HF risk factors including AF, BMI, HDL-C, systolic blood pressure, renal dysfunction, CRP and cardiac function (NT-proBNP and cTnT). The gene discussed is TNNT2; the disease is Abnormal renal physiology.