These findings are in agreement with those of Lepley et al., who found that S1P mediated formation of stress fibres and the inhibition of glioblastoma cell migration was dependent on S1PR2/Rho/ROCK [31], although studies of CHO cells that over-express S1PR2 suggest that Rho-kinase-independent mechanisms for S1PR2/Gα12/13/Rho regulating cell migration [17] also exist. Here, RHO is linked to glioblastoma.