NMR spectra from 108 patients (34 RRMS, 54 AQP4-Ab NMOSD, and 20 MOG-Ab disease) were included in this study (Fig. 1) to determine whether we could generate model algorithms that could accurately distinguish between plasma samples from patients with RRMS, AQP4-Ab NMOSD or MOG-Ab disease. Here, AQP4 is linked to glycogen storage disease VI.