ANXA5 and familial pancreatic carcinoma: The Annexin V staining apoptosis assay was used to determine whether stimulation with metamizole, MAA, and paracetamol or the combination of metamizole and paracetamol caused apoptosis or necrosis in the pancreatic cancer cell lines PaTu 8988t (Fig. 2) and Panc-1 (Fig. 3).