IGFBP6 and renal cell adenocarcinoma: As shown in Table 3, the most significantly enriched gene categories are involved in insulin-like growth factor binding, transmembrane transport of small molecules, cocaine, amphetamine addiction, etc. Interestingly, seven of the 44 candidate genes (ASS1, DEFB1, IGFBP6, LCN2, SERPINA5, UMOD and VCAN) were indeed overrepresented in the “Renal-cell cancer” gene set (p < 1.4 E-5).