The AUC for MMP-9 adjusted by gender, age and smoking history (0.787) practically did not increase when combined with either MMP-1, MMP-7 or both MMP-1 and MMP-7 (AUC of 0.787,0.786 and 0.788, respectively), indicating that these MMPs do not complement MMP-9 to separate cancer patients from controls. This evidence concerns the gene MMP1 and cancer.