Similarly, 388 T2DM patients using RASi inhibitors, losartan or irbestartan in the RENAAL and IDNT trials, showed a 30% reduction in albuminuria 3 months after commencement of RASi inhibition and a further decrease of 44.8% in 174 patients after 12 months [30]. Here, MMP19 is linked to type 2 diabetes mellitus.