In previous studies, we reported that the ligation of LFA-1 expressed on tumor cells with endothelial ICAM-1 induced the production of ManR-stimulating factors from C26 cells, including IL-1, VEGF and sICAM-1 [4, 12], mediated by the activity of COX-2 in tumor cells. The gene discussed is IL1B; the disease is neoplasm.