Lymphocyte Function Associated Antigen (LFA)-1 (CD11a/CD18 or αLβ2) is a heterodimeric protein of the integrin family expressed on the surface of nearly all leukocytes [5] and recently described on a variety of tumor cells [1, 6, 7] including colorectal cancer cells [8, 9]. The gene discussed is ITGB2; the disease is colorectal cancer.