Moreover, either the ManR blockage on tumor-stimulated LSECs or the neutralization of ManR stimulating factors derived from sICAM-1 activated tumor cells, such as Interleukin (IL)-1β inducing factors and Cyclooxygenase (COX)-2-dependent factors, restored the cytotoxicity of LSLs towards the cancer cells after their interaction with tumor-activated LSECs [4]. The gene discussed is PTGS2; the disease is neoplasm.