Interestingly, the adhesion of C26 cells to LSEC was affected only by β2 partial deficiency or by anti-CD11a neutralization, but not by tumor CD11b/c nor VCAM-1 blockade on LSECs, a ligand for the integrin CD49d (α4β1), confirming a role for LFA-1 on tumor metastasis development of colorectal cancer to the liver. This evidence concerns the gene ITGAL and colorectal cancer.