Some reports suggest that CD11b+ Ly6G+ might accumulate in the liver due to tumor-derived inflammatory factors such as PGE2 of COX-2 origin [39], VEGF [40] and IL-1β [41], released by LSECs after interacting with tumor cells via LFA-1/ICAM-1 [4, 12]. The gene discussed is ITGB2; the disease is neoplasm.