Furthermore, expression of IGF1R vs. activity of the signaling pathway (i.e. pIGF1R and activation of IGF1R signaling) play an integral oncogenic role in cancer and likely add to the discrepancy between studies and analysis (i.e. gene vs protein) reporting the prognostic and therapeutic significance of whether blocking IGF1R activity and/or expression is more beneficial in cancer [12]. This evidence concerns the gene IGF1R and cancer.