However, our immunohistochemistry findings in this study report the opposite effect for protein expression (i.e. improved OS in ER-positive disease), further highlighting the ongoing discrepancy in findings relating to the relationship between high IGF1R expression and ER-positive breast cancer potentially based on different prognostic parameters (i.e. protein vs gene, patient tumor cohorts, antibodies, cut-off and pIGF1R vs. IGF1R measurements i.e. signalling vs. expression) [12]. The gene discussed is IGF1R; the disease is neoplasm.