After adjustment for age, sex, the previous history (cardiovascular diseases, hypertension and diabetes), using angiotensin-converting enzyme inhibitors (ACEI)/angiotensin II receptor blocker (ARB), proteinuria, and eGFR at baseline, persistent hematuria remained an independent predictor of the renal outcomes in the multivariate analysis (Table 3). The gene discussed is ACE; the disease is Hypertension.