CD44 and cancer: In this context, CD44, a member of the transmembrane glycoprotein family commonly implicated in cell-cell and cell-matrix interactions, cell proliferation, differentiation, migration, angiogenesis, presentation of cytokines, chemokines, and growth factors to the corresponding receptors, docking of proteases at the cell membrane, and cell survival [107-109], has been implicated as a cancer stem cell (CSC) marker in several malignancies [110-114].