KDM4C and Familial prostate cancer: Furthermore, Lee et al. also revealed that, in human LNCaP prostate cancer cells, the hypoxia situation increased the levels of JMJD2C protein, and the pathological hypoxia (< 0.5% O2) brought about the abnormal variations of epigenetic genes through modifying the quantity and activity of JMJD2C because of the existence of H3K9me3 (the substrate for JMJD2C).