JMJD2C was considered as an oncogene due to its firstly discovered in primary Hodgkin lymphoma and mediastinal B-cell lymphoma, in which both of JMJD2C and tyrosine kinase JAK2 (Janus kinase 2) were found to have the function of epigenetic regulation. The gene discussed is KDM4C; the disease is Hodgkins lymphoma.