PDK1 and breast cancer: suggested in breast cancer cells that [39], increased expression of JMJD2C activated the transcription of PDK1 (Pyruvate Dehydrogenase Kinase 1), LDHA (Lactate Dehydrogenase A), BNIP3 (BCL2 Interacting Protein 3) and SLC2A1 (Solute Carrier Family 2 Member 1), and all of their encoded proteins [60–63] were required for metabolic reprogramming thereby stimulating HIF-1-dependent reprogramming.