More importantly, comparing with other members of JMJDs family, JMJD2C had the highest frequency (13.4%) of genetic alteration including mutation, homozygous deletion, high-level amplification, mRNA downregulation, and mRNA upregulation among 976 breast cancer specimens, and all the 976 Cancer Genome Atlas (TCGA) data for breast cancer were from cBio Cancer Genomics (http://cbioportal.org) database [59]. The gene discussed is KDM4C; the disease is breast cancer.