IHC revealed (i) variable glial fibrillary acidic protein (GFAP)-positive staining of tumor cells and constant and strong staining of reactive astrocytes (Figure 3A), (ii) Iba-1/CD68-positive staining of reactive ramified microglia (Figure 3B) and macrophages (Figure 3C), (iii) CD34-positive staining of endothelial cells (Figure 3C) and IDH1R132H-negative immunostaining. The gene discussed is AIF1; the disease is neoplasm.