MIB1 and neoplasm: Pattern 1 (P-1) corresponded to the CE region characterized by the highest values of cell and vessel density, nuclear polymorphism, Ki-67/MIB-1 LI, circumscribed necroses and endothelial hyperplasia; pattern 2 (P-2) was characterized by highly infiltrated tissue with satellitosis or tumor cell co-option with neoangiogenesis or microvascular proliferations (MVPs); pattern 3 (P-3) was characterized by a mild peripheral tumor infiltration without neoangiogenesis and MVPs; pattern 4 (P-4) was characterized by tumor infiltration with peritumor edema.