SAMD4B and cancer: More interestingly, seven different genes (ECH1, PEX5, MLF2, NFIX, TSPAN9, SAMD4B, and NFKBIB) were associated with another drug C646, which is a small molecule inhibitor targeting histone acetyltransferase p300, an enzyme that alters the cancer transcriptome in the lung [35], colon and pancreas [36].