While BMN11 showed no cytotoxicity in cell lines including HaCat (human keratinocyte), B16F10 (mouse melanoma), and Hs27 (human fibroblast) up to 30 μM (Figure 4a), αMSH-induced tyrosinase activity (Figure 4b) and melanogenesis (Figure 4c) were notably decreased by BMN11 treatment in a concentration-dependent manner, suggesting that BMN11 efficiently inhibits αMSH-mediated melanogenesis. Here, TYR is linked to melanoma.