FZD7 and cancer: Fzd7 is frequently up-regulated in a variety of cancers including colon cancer [6, 7], breast cancer [8], hepatocellular carcinoma [9, 10], lymphoblastic leukemia [11], Wilm’s tumors [12, 13], glioblastoma [14], ovarian cancer [15] melanoma [16], chronic myeloid leukemia [17] and gastric cancer [18].