VHL and hepatocellular carcinoma: Accordingly, EF24, a curcumin analog, overcomes sorafenib resistance promoting the VHL-dependent HIF-1α degradation [2], the histone deacetylase inhibitor vorinostat has been shown to inhibit HIF-1α translation through the eukaryotic translation initiation factor 3 subunit G (eIF3G) repression [44], and several miRNAs, such as miR-338-3p and miR-199a-5p, sensitize HCC models to sorafenib by targeting HIF-1α [45, 46].