MMP1 and cancer: High expression of MMP1 has been identified in various kinds of cancers, and its overexpression has been proved to be correlated with unfavorable clinical outcome in malignancies such as hepatocellular carcinoma [5], gallbladder carcinoma [6], thyroid carcinoma [7], pancreatic carcinoma [8], esophageal cancer [9], gastric cancer [10] and colorectal cancers [11].