MMP1 and breast cancer: The Kaplan-Meier curve and log-rank test analyses showed that increased levels of MMP1 were significantly correlated with worse overall survival (OS) (HR = 1.6; 95% CI: 1.29 - 1.99, p = 1.6e-05), relapse free survival (RFS) (HR = 1.78; 95% CI: 1.59 - 1.98, p < 1E-16) and distant metastasis free survival (DMFS) (HR = 1.65; 95% CI: 1.35 - 2, p = 5.3e-05) for BC patients (Figure 3B–3D).