We observed that NC decreased tumor volume and weight, increased the number of TUNEL-positive cells (Figures 5A, 5B and 5C), and showed distinctly reduced protein expression levels of phospho-STAT3 in the tumors of NC-treated mice compared to the tumors of vehicle-treated mice (Figure 5D), consistent with our in vitro data. The gene discussed is STAT3; the disease is neoplasm.