Zhou et al. reported that SOCS2 attenuated STZ-induced renal lesions including renal/glomerular hypertrophy, glomerular hyperfiltration, aberrant inflammation and fibrosis and reduced the levels of proinflammatory proteins (TGF-β, collagen IV and fibronectin) in DN [25]. The gene discussed is FN1; the disease is liver dysplastic nodule.