EGFR and non-small cell lung carcinoma: Recently, targeted therapies involving the use of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) were reported to be beneficial for NSCLC patients, but the response to EGFR-TKIs was limited mainly to NSCLC patients carrying EGFR mutations (50% of Asian patients and 15% of Western patients), and ∼20%–30% of these patients failed to respond to the drugs [4].