Interestingly, the opposite regulatory relationship between Rnd3 and Notch1 signaling has been reported recently in squamous cell carcinoma, in a study that showed that Rnd3 was a transcriptional target of Notch1, and that Rnd3 promoted Notch signaling by facilitating NICD nuclear translocation through importin β1 in skin epithelial cancer cells [24]. The gene discussed is NOTCH1; the disease is squamous cell carcinoma.