TMEM97 and uveal melanoma: Since cinnarizine significantly inhibited (+)-[3H]- (+)-pentazocine binding (IC50 = 162 ± 28 nM), and a QSAR study predicted a high Sigma-2 (σ2) receptor affinity, we hypothesized that Sigma (σ) receptors could play also a role in uveal melanoma progression [10–13].