ASPG and B-cell chronic lymphocytic leukemia: Except for being proved for treatment of ALL, asparaginase is also reported to be effective in treatment of other kinds of leukemia including non-Hodgkin’s lymphoma [18], acute myelocytic leukemia (AML) [19, 20], chronic myelocytic leukemia (CML) [21], chronic lymphocytic leukemia (CLL) and several malignant solid cancers such as melanosarcoma [22, 23], ovarian cancer [24, 25] and pulmonary adenocarcinoma (ADCA) [26].