PRDX1 and brain ischemia: Considering the potent antioxidative effects of Gas-D against H2O2-induced oxidative stress in vitro and in brain ischemia in vivo, we hypothesize that Gas-D inhibits redox-dependent Prx1/2/4 signaling and subsequent immunoinflammatory responses after cerebral ischemia by restoring the postischemic redox imbalance.