Moreover, the high expression of NF-κB and MMPs has also been demonstrated in poorly differentiated nasopharyngeal carcinoma cell lines with high expression of HSPB1, suggesting that HSPB1 might enhance the invasion, proliferation and migration of nasopharyngeal carcinoma cells through the activation of the NF-KB signaling pathway and increased expression of MMPs. This evidence concerns the gene NFKB1 and nasopharyngeal carcinoma.