We were able to find a strong interaction between cyclin A2 and MRE11 mRNA in the control siRNA-transfected MCF-7 cells (Figure 3B), suggesting that the RNA binding property of cyclin A2 is also conserved in breast cancer cells and that the decreased abundance of MRE11 protein in the cyclin A2 siRNA-transfected cells may be due to the lack of cyclin A2 binding onto the MRE11 mRNA. The gene discussed is MRE11; the disease is breast cancer.