TRPV1 and T-cell leukemia: In this regard, TRPV1 is a cation channels expressed on thymocytes as well as on naïve and effector CD4+ T lymphocytes and Jurkat T cell leukemia [12, 13], and a contribute of TRPV1 in TCR-induced Ca2+ influx and proper downstream TCR signaling leading to T cell activation has been recently reported [14].