In stage I squamous cell carcinomas, a multivariate model where variables with p<0.10 in univariate survival analysis (BVI and SerpinB2) were included, showed that high SerpinB2 was an independent prognostic factor for reduced LCSS (HR 3.5 (95 % CI 1.03-11.74), p = 0.044) (Supplementary Table 10B). This evidence concerns the gene SERPINB2 and squamous cell carcinoma.