In a multivariate model for AC where sex, histologic grade (high versus low), blood vessel invasion (present versus absent), lymphatic vessel involvement (present versus absent), necrosis (present versus absent), tumor stage (II-IV versus I), and SerpinB2 expression (low versus high) were included, low SerpinB2 demonstrated independent prognostic value for LCSS (HR 1.8 (95% CI 1.17-2.06), p = 0.008) (Table 2). The gene discussed is SERPINB2; the disease is neoplasm.