Investigations of the underlying mechanisms have shown that downregulation of the level of expression of Miro1 after a continuous challenge with an HFD, leads to imbalance activation of MKK-JNK-IRS1307 downstream and inhibition of AKT-Foxo1 phosphorylation cascades, promotion of IKO mouse pancreatic islet insulin resistance, inflammatory response and metabolic disorders, thereby the resultant T2D (Figure 6). This evidence concerns the gene MAPK8 and metabolic disease.