Although it has also been shown that RPL22/eL22 deficiency leads to the activation of the tumor suppressor p53 in immune cells, and RPL22/eL22 may mediate Trp53 translation via Miz1 in cells undergoing V(D)J recombination [6, 7], it still remains unknown if RPL22/eL22 might play a possible tumor suppression role by regulating the p53-MDM2 loop in response to ribosomal stress in non immune cells since RPL22/eL22 is ubiquitously expressed in all cells and tissues. This evidence concerns the gene RPL22 and neoplasm.