TP53 and malignant colon neoplasm: Next, we checked if RPL22/eL22 can lead to the p53-dependent suppression of cancer cell colony formation by using two sets of cancer cell lines, including lung cancer (H1299p53-/- and H460p53+/+) and colon cancer (HCT116p53-/- and HCT116p53+/+) cell lines.