RPL22 and neoplasm: Interestingly, differing from other ribosomal protein genes whose deletion mutations are underrepresented in TP53-intact tumors due to negative-selection pressure, RPL22/eL22 deletion/mutation tends to occur in wild-type TP53 harboring tumors and cancer cell lines [5] (Figure 3E), further supporting its tumor suppressor role through activations of p53.