HMGCR and hepatocellular carcinoma: However, preliminary data from our group show that suppression of HSF1 by siRNA or KRIBB11 has no effects on the levels of CDK9, ARK5, HMGCR, or CSNK1e in HLE and HLF cell lines (unpublished observation), implying that other genes modulated by HSF1 might eventually influence c-Myc activity in HCC cells.