Despite the assessment of local/systemic complications, it was recently demonstrated that Serum Soluble Fms-Like Tyrosine Kinase 1 (sFlt-1) [29], serum uromodulin [30], and serum neutrophil gelatinase-associated lipocalin (NGAL) [31] could serve as reliable early predictors of AP severity. The gene discussed is FLT1; the disease is alkaline phosphatase measurement.