Importantly, major genetic and signaling aberrations in IDH-wildtype GBM including mTORC2 (in the EGFR-mTOR pathway) and TERT (telomerase reverse transcriptase) play an important role in transcriptional regulation and metabolic reprogramming [70,71], possibly linking genetic mutations and invasive phenotypes through metabolic reprogramming (Figure 3). The gene discussed is IDH2; the disease is glioblastoma.